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Clinical Research & Resources

Stay up to date with these resources and Web sites dedicated to Alpha-1 research and clinical trials.

Alpha-1 Educational Materials

Please refer to the following organizations which provide educational materials on Alpha-1:

Downloadable tools

The following tools help people with Alpha-1 better understand and manage their condition. Check back frequently; new tools are added periodically.

You need the Adobe® Reader® installed on your computer to view PDFs. You can download a copy of the Adobe Reader by clicking the link below.

ADOBE LOGO/LINK

Adobe and Adobe Reader are registered trademarks of Adobe Systems Incorporated.

What is Alpha-1 Antitrypsin Deficiency?

What does it mean to be an Alpha-1 Carrier?

Guide for the Recently Diagnosed

Big Fat Reference Guide (Registration with AlphaNet required)

Additional Alpha-1 Resources

The Alpha-1 community is served by the following not-for-profit organizations providing support and services:

  • AlphaNet provides enrollment assistance to patients receiving PROLASTIN-C through the Prolastin Direct Patient ServicesSM Program, helps coordinate their care, and distributes the Big Fat Reference Guide, a comprehensive guide to living with Alpha-1. AlphaNet helps coordinate information on insurance and nursing care, ordering infusion supplies, additional education and support, and free Alpha-1 test kits and information about testing. To learn more, call 800-577-2638 or visit www.alphanet.org
  • The Alpha-1 Foundation is the only national organization dedicated to developing a cure for Alpha-1 and to improving the quality of life for those with the disorder. The Foundation is guided by representatives of the Alpha One Foundation, the medical and scientific communities. To learn more, call 877-2-CURE-A1 (877-228-7321) or visit www.alphaone.org
  • The Alpha-1 Association is a nonprofit organization helping patients with Alpha-1 and acting as a patient advocate. Through the association, people with Alpha-1 can meet others with Alpha-1. There are chapters across the country. To learn more, call 800-521-3025 or visit www.alpha1.org 

Important Safety Information

PROLASTIN-C, Alpha1-Proteinase Inhibitor (Human) is indicated for chronic augmentation and maintenance therapy in adults with emphysema due to deficiency of alpha1-proteinase inhibitor (alpha1-antitrypsin deficiency). The effect of augmentation therapy with any alpha1-proteinase inhibitor (alpha1-PI) on pulmonary exacerbations and on the progression of emphysema in alpha1-antitrypsin deficiency has not been demonstrated in randomized, controlled clinical trials. PROLASTIN-C is not indicated as therapy for lung disease in patients in whom severe Alpha1-PI deficiency has not been established.

PROLASTIN-C may contain trace amounts of IgA. Patients with known antibodies to IgA, which can be present in patients with selective or severe IgA deficiency, have a greater risk of developing potentially severe hypersensitivity and anaphylactic reactions. PROLASTIN-C is contraindicated in patients with antibodies against IgA.

The most common drug related adverse reactions during clinical trials in ≥ 1% of subjects were chills, malaise, headache, rash, hot flush, and pruritus.

PROLASTIN-C is made from human plasma. Products made from human plasma may carry a risk of transmitting infectious agents, e.g., viruses, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

Please see accompanying PROLASTIN-C Full Prescribing Information for complete prescribing details.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.